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10 sample questions
Emergency Medicine MCQ Practice Test
Acute condition stabilization
Q1. A 35-year-old woman presents to the emergency department with a 2-hour history of severe headache, confusion, and fever. She has a history of migraines and is on topiramate. Her vitals are BP 160/100, HR 110, and T 38.5°C. Laboratory results show a slightly elevated WBC count and a positive urine dipstick for ketones. Which of the following is the most appropriate initial treatment?
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A. Administer IV acetazolamide and repeat the urine dipstick in 1 hour.
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B. Administer IV labetalol and obtain a CT scan of the head. ✓
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C. Administer IV saline and administer a low-dose dopamine infusion.
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D. Administer IV naloxone and repeat the urine dipstick in 1 hour.
Explanation: The patient's presentation is concerning for a hypertensive emergency and possible neurological involvement. The elevated blood pressure, headache, confusion, and fever warrant immediate management of the hypertension and investigation into the cause of the neurological symptoms. IV labetalol is a suitable medication to rapidly lower blood pressure. A CT scan of the head is indicated to rule out intracranial hemorrhage or other structural causes of the headache and altered mental status. The ketones in urine are less concerning than the other symptoms and do not dictate immediate treatment.
Q2. A 35-year-old woman presents to the emergency department with a 2-day history of severe headache, fever, and confusion. She has a history of systemic lupus erythematosus (SLE) and is on long-term corticosteroid therapy. Laboratory results show a leukocyte count of 18,000/uL, platelet count of 80,000/uL, and a positive Coombs test. Which of the following is the most appropriate initial treatment for this patient?
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A. Administer high-dose corticosteroids to reduce inflammation
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B. Initiate plasmapheresis to remove autoantibodies ✓
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C. Order a lumbar puncture to rule out meningitis
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D. Prescribe antithrombotic therapy to prevent thrombosis
Explanation: This patient is likely experiencing SLE-related thrombotic thrombocytopenic purpura (TTP), which is a life-threatening complication of SLE. Plasmapheresis is the most appropriate initial treatment to remove autoantibodies and prevent further thrombosis.
Q3. A patient with severe symptomatic hyponatremia (confusion, seizures) should initially be treated with:
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A. intravenous 3% hypertonic saline ✓
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B. intravenous furosemide
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C. oral demeclocycline
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D. intravenous 5% dextrose in water
Explanation: Severe symptomatic hyponatremia is treated with a bolus of intravenous 3% hypertonic saline to raise serum sodium and stop seizures or cerebral edema. D5W lowers sodium further; furosemide and demeclocycline are not initial therapy for acute symptomatic cases.
Q4. What is the immediate first-line treatment for anaphylaxis presenting with stridor and respiratory distress?
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A. Intramuscular epinephrine ✓
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B. Epinephrine 1:1000 via endotracheal tube
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C. Nebulized albuterol alone
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D. Oral diphenhydramine alone
Explanation: Anaphylaxis is treated immediately with intramuscular epinephrine (typically 0.5 mg of 1:1000 in the thigh). The endotracheal route is an obsolete last-resort route only during cardiac arrest intubation; antihistamines and albuterol are adjuncts, not first-line.
Q5. A 35-year-old woman presents to the emergency department with a 2-hour history of severe headache, fever, and confusion. She has a history of migraines but this episode is different. Her blood pressure is 220/120 mmHg. Which of the following is the most appropriate initial treatment?
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A. Administer a sublingual nitroglycerin to reduce blood pressure and relieve headache
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B. Order a non-contrast head CT to rule out hemorrhage before initiating treatment ✓
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C. Start a dopamine antagonist such as metoclopramide to reduce headache severity
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D. Begin a calcium channel blocker such as nimodipine to reduce blood pressure and relieve headache
Explanation: The patient's presentation is suggestive of a hypertensive emergency, but the first step is to rule out a hemorrhagic stroke, which would be a contraindication for antihypertensive therapy. A non-contrast head CT is the most appropriate initial imaging study.
Q6. A 35-year-old woman presents to the emergency department after a motor vehicle collision. She is found to have a thoracic spine fracture and is at risk for spinal cord injury. Which of the following medications is most appropriate for her management?
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A. Methoxyflurane for pain control
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B. Ketamine for sedation ✓
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C. Naloxone for opioid overdose reversal
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D. Succinylcholine for muscle relaxation
Explanation: Ketamine is the preferred choice for sedation in patients with spinal cord injuries because it does not depress respiration or circulation, and it can help to maintain blood pressure. Methoxyflurane is an older anesthetic agent that can cause renal toxicity and is not preferred for pain control. Naloxone is used to reverse opioid overdose, and succinylcholine is a depolarizing muscle relaxant that can cause hyperkalemia in patients with spinal cord injuries.
Q7. A hospital without PCI capability gives a patient with an inferior STEMI a thrombolytic. What is the guideline-recommended next step?
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A. Urgent transfer to a PCI-capable center for angiography ✓
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B. Aspirin and routine ward monitoring only
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C. A beta-blocker and an exercise stress test next week
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D. Discharge home the following day
Explanation: After fibrinolysis, guidelines recommend transfer to a PCI-capable hospital for angiography (pharmacoinvasive strategy) to assess reperfusion and manage reocclusion. Simple monitoring understreatments an acute MI.
Q8. A 35-year-old woman presents to the emergency department with a 2-day history of severe headache, fever, and confusion. She has a history of migraines but this episode is different. Her vital signs are: temperature 38.5°C, blood pressure 160/90 mmHg, pulse 110 bpm, and respiratory rate 24 breaths/min. A non-contrast CT scan of the head shows no evidence of hemorrhage or infarction. What is the appropriate initial treatment for this patient?
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A. Administer high-dose dexamethasone and start a trial of anticoagulation with heparin.
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B. Order a lumbar puncture to obtain cerebrospinal fluid for analysis. ✓
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C. Start a course of intravenous acetazolamide and provide supportive care.
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D. Initiate a trial of hypertonic saline and mannitol to reduce intracranial pressure.
Explanation: This patient's presentation is suggestive of aseptic meningitis, likely caused by viral or bacterial pathogens. A lumbar puncture is necessary to obtain cerebrospinal fluid for analysis, which will help guide further management and treatment. The other options are not appropriate for this patient's presentation.
Q9. A 25-year-old patient presents to the emergency department after a motor vehicle collision with a suspected diagnosis of a thoracic aortic injury. Which of the following medications is most likely to be administered to this patient?
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A. Norepinephrine for vasopressor support
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B. Sildenafil for vasodilation
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C. Clonidine for hypertension management
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D. Nitroprusside for acute aortic dissection ✓
Explanation: In the setting of a suspected thoracic aortic injury, the administration of nitroprusside is often used to control blood pressure and reduce the risk of further aortic damage. This is because nitroprusside is a potent vasodilator that can be titrated to achieve the desired blood pressure, and it is often used in the management of acute aortic dissection.
Q10. A 35-year-old woman with a history of systemic lupus erythematosus (SLE) on long-term corticosteroid therapy presents to the emergency department with a 2-day history of severe headache, fever, and confusion. Laboratory results show a low platelet count (thrombocytopenia) and elevated liver enzymes. She admits to taking an excessive amount of acetaminophen over the past 24 hours. Which of the following is the most appropriate initial treatment for this patient?
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A. Methylprednisolone for severe SLE flare
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B. High-dose IVIG for suspected SLE-related thrombocytopenia
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C. N-acetylcysteine (NAC) and supportive care for acetaminophen overdose ✓
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D. Mannitol and hypertonic saline for suspected cerebral edema
Explanation: This patient's presentation of severe headache, fever, confusion, thrombocytopenia, and elevated liver enzymes, along with the history of excessive acetaminophen intake, strongly suggests acetaminophen-induced liver injury. N-acetylcysteine (NAC) is the antidote for acetaminophen overdose and should be administered promptly, along with supportive care.
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